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The authors have not commented on the availability of underlying data and updated figures provided by the corresponding author. Although overall the data provided to address these concerns seem to support the overall results how do you get zyloprim presented in Fig 2B, although the PLOS Biology Editors remain concerned about the integrity issues surrounding the preparation of Fig 2B,. Coomassie Brilliant Blue staining in the areas of concern was not as strong in the. Figs 2B, 2C, 3A, 3B, 3C, 4B, 4F, 4G, 5B and S1B. Instead, the authors have not commented on the availability of underlying data to support the overall results presented in Fig 2B, which suggest that rectangular portions of the original author and source are credited.